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Of 50, HIV-infected women with antenatal visits between January and September , 4, women met the inclusion criteria. These findings were consistent across several sensitivity analyses. Longer duration of cART was not associated with poor fetal growth among term pregnancies in our cohort. However, the relationship between cART and adverse pregnancy outcomes remains complicated.
Continued work is required to investigate causality. However, cART use during pregnancy could negatively affect fetal growth. Duration of cART during pregnancy is directly related length of gestation, making it difficult to meaningfully assess the association between duration of treatment and PTB. We, therefore, limited our analysis cohort to those infants delivered at term.
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We demonstrate the use of multiple overimputation to address missing data and measurement error in gestational age. Using routinely collected clinical data from public health facilities in Lusaka, Zambia, we multiply imputed missing data and multiply overimputed observed values of gestational age. Poisson models with robust variance estimators were used to estimate risk ratios RRs for the associations of duration of combination ART with small for gestational age SGA and preterm birth.
We compared results from a complete-case analysis, using multiple imputation to address missing data only, and using multiple overimputation to address missing data and measurement error. In the complete-case analysis, there was no evidence of an association between duration of combination ART and SGA or preterm birth.
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